Jeong Woo Koo
Ph.D. Candidate, Materials Science and Engineering
"Mechanically interlocked structures, like chain links, combine strength with the freedom to move and change shape in ways that neither bulk solids nor loose particles can. Their properties depend on both their ingredients and how their components are linked. Our team’s earlier work on polycatenated architected materials (PAMs) showed that three-dimensional networks of interlocked components can flow like fluids under small loads yet resist deformation like solids under larger ones.
The unresolved challenge is to bring this mechanical freedom into an ordered three-dimensional crystal at the nanoscale. Conventional DNA crystals are held together by fixed connections, while interlocked molecular chains lack long-range three-dimensional order. How mechanical interlocking governs collective ordering, thermal stability, and phase behavior under constant thermal motion remains poorly understood. My research addresses this gap by developing polycatenated DNA crystals: repeating structures of interlocked nanoscale cages that can slide and rotate while staying connected.
I build these structures using DNA origami, a technique that folds DNA into precisely designed 3D shapes. I design tripod building blocks that assemble into cages. Changing the angles between their arms produces tetrahedral or cubic cages, then I guide the cages to thread through one another as they grow into a crystal, followed by protecting the architecture with thin silica coatings.
These crystals would help us understand how interlocked components organize and rearrange without losing their connections. This understanding could lead to responsive layers that stay flexible in everyday use but stiffen under impact, or to optical surfaces that change how they interact with light when pressed, stretched, or heated. The same controlled motion could also support nanoscale robotic components and mechanical computing, where information is stored and processed through changes in physical configuration."
Dr. Wenjie Zhou
Advisor, Materials Science and Engineering
"Jeong Woo’s work advances our vision for a new type of soft matter: materials whose separate building blocks can rearrange while remaining inseparably linked. This gives us a new way to combine the cohesion of solids with the mobility of particles. He uses geometry-guided inverse design, working backward from a desired arrangement to design nanoscale cages that assemble into an ordered, interlocked network. Achieving this would open a previously inaccessible system for understanding how matter organizes and changes its behavior when its parts can move but cannot separate. PPG’s support helps him establish that foundation, with long-term opportunities in responsive coatings with tunable mechanical, acoustic, and optical properties."